Pharmacology and Toxicology

Leader of the research programme:

Professor Dr. Pavel Anzenbacher, D.Sc.
Professor Dr. Jitka Ulrichová, PhD.

Pharmacology and Toxicology research program focuses on elucidation of how and if a biologically active substance is absorbed
into the organism, transformed by the organism and whether it is not toxic within the range of therapeutic concentrations
and no negative interactions with other concurrently administered substances are observed. Initial step in the research
plan is usually identification and optimization of administration route into the body, next is verification of pharmacokinetics
linearity by testing dose and time dependence in series with various doses and finding the basic pharmacokinetic parameters
using a suitable experimental model. Further, the substance distribution pattern is investigated in order to detect its presence
or absence in the most important tissues and organs of experimental model organisms or in clinical trials.

Deliverables: 1. Pharmacokinetic and pharmacodynamic studies of compounds that will closely replicate the clinical situation and will be potentially used for registration studies; 2. Cellular toxicity of tested substances; 3. Chemoprotective and biosafety studies of tested substances; 4. Studies on toxicity and use of photosensitizers in photodynamic therapy. All deliverables will start from 2013 and will be published in the form of papers, research reports, patents and conference presentations.

Key methodological approaches: Genomics, proteomics, metabolomics, bioanalytics, in vivo and in vivo toxicology and metabolism