Molecular basis of diseases and molecular target

Leader of the research programme:

Professor Jiří Bártek, MD., PhD.
Professor Martin Petřek, PhD.

Research program aims at identification and description of metabolic pathways, signaling pathways, genetic and epigenetic
changes causing human diseases, particularly focusing cancer, inflammatory and infectious diseases. Results obtained help
in selecting a target molecule, most frequently a gene or protein, through which it is possible to design a drug or biomarker
and thus influence the disease outcome. Strong expertise is in regulation of DNA damage and repair in normal, inflammatory
and cancer cells.

Deliverables: 1. Identification of novel genes/pathways involved in the process of control and maintenance of genomic integrity; 2. Novel methodical protocols allowing investigation and monitoring of influence of environmental factors on genomic integrity in humans; 3. Genetic, epigenetic and proteomic changes in health and disease – identification of novel molecular targets an pathophysiology in cancer and infectious diseases. Deliverables will be published in the form of papers, research reports, patents and conference presentations.
Key methodological approaches: Genomics, proteomics, metabolomics, pan-genome screening for molecular targets